SP Elixir (OPC) Private Limited

Apretero (Aprepitant) capsules are a type of medication primarily used to prevent nausea and vomiting associated with chemotherapy and surgery. Aprepitant is part of a class of drugs known as NK1 receptor antagonists.

How It Works:

Aprepitant works by blocking the neurokinin 1 (NK1) receptor in the brain, which plays a key role in triggering nausea and vomiting. Specifically, it blocks the action of substance P, a substance in the body that binds to the NK1 receptor and can cause nausea. By inhibiting this receptor, Aprepitant helps prevent nausea and vomiting associated with chemotherapy treatments or post-surgery recovery.

Uses:

• Chemotherapy-induced nausea and vomiting (CINV): It is often prescribed as part of a combination therapy to prevent nausea and vomiting in cancer patients undergoing chemotherapy, especially those receiving highly emetogenic (vomit-inducing) chemotherapy.
• Post-operative nausea and vomiting (PONV): It is also used to prevent nausea and vomiting after surgery.

Dosage:

• Chemotherapy-induced nausea and vomiting (CINV): Aprepitant is usually taken once daily for 3 days, starting with a dose before chemotherapy. It is often given alongside other antiemetic medications.
• Post-operative nausea and vomiting (PONV): A single dose is typically taken one hour before surgery.

The typical dosage for adults is usually 40 mg to 125 mg, depending on the specific treatment protocol, and your doctor will provide instructions for your individual needs.

Side Effects:

Some possible side effects of Aprepitant include:

• Fatigue
• Headache
• Constipation
• Hiccups
• Loss of appetite
• Dizziness

Important Information:

• Drug Interactions: Aprepitant can interact with several other medications, including certain chemotherapy drugs, anticoagulants, and birth control pills. Always inform your doctor about other medications or supplements you are taking.
• Pregnancy and Breastfeeding: Aprepitant is classified as a Category B drug during pregnancy, meaning it may be safe for use during pregnancy, but it should only be used if clearly needed. Always consult your doctor if you're pregnant or breastfeeding.
• Liver Function: Aprepitant may need dose adjustments in patients with liver problems, so your doctor will monitor liver function.

Administration:

• Aprepitant is usually taken orally, and it can be taken with or without food.
• Swallow the capsule whole, and do not crush or chew it.

If you are prescribed Apretero (Aprepitant), make sure to follow the prescribed dosage and treatment plan provided by your healthcare provider. If you experience any unusual symptoms or side effects, notify your healthcare provider immediately.

Veenat 100mg Capsules contain Imatinib Mesylate, an oral targeted therapy medication primarily used to treat various types of cancer, including chronic myelogenous leukemia (CML) and certain types of gastrointestinal stromal tumors (GISTs).

Key Information:

• Active Ingredient: Imatinib Mesylate.
• Class: Tyrosine kinase inhibitor (TKI).
• Mechanism of Action: Imatinib works by blocking specific enzymes called tyrosine kinases. These enzymes are involved in the growth and spread of cancer cells. By inhibiting these enzymes, Imatinib helps to stop the cancer cells from growing and dividing, leading to tumor shrinkage or stabilization of the disease.

Common Uses:

1. Chronic Myelogenous Leukemia (CML): Used for treating CML, particularly in the Philadelphia chromosome-positive (Ph-positive) variant, by targeting and inhibiting the BCR-ABL fusion protein, which drives the abnormal growth of white blood cells.
2. Gastrointestinal Stromal Tumors (GISTs): Imatinib is used to treat GISTs, a type of cancer that starts in the gastrointestinal tract, by targeting and blocking the abnormal KIT (stem cell factor receptor) protein that promotes cancer cell growth.
3. Other cancers: Imatinib is also used for treating other cancers, such as acute lymphoblastic leukemia (ALL), myelodysplastic/myeloproliferative diseases, and certain types of soft tissue sarcomas.

Administration:

• Oral capsule typically taken once or twice daily, with or without food, based on the doctor’s instructions.
• It should be taken with a full glass of water to reduce the risk of stomach irritation.

Side Effects:

• Nausea and vomiting.
• Diarrhea.
• Fluid retention (swelling in the legs, ankles, or around the eyes).
• Fatigue.
• Muscle cramps or pain.
• Headache.
• Rash.
• Liver toxicity: Imatinib can cause liver function abnormalities, which may require periodic liver tests.
• Low blood counts: This can lead to anemia, leukopenia (low white blood cell count), or thrombocytopenia (low platelet count), increasing the risk of infections or bleeding.
• Heart problems: In rare cases, Imatinib can cause heart failure or fluid retention in the lungs, particularly in patients with pre-existing heart conditions.

Precautions:

• Pregnancy and breastfeeding: Imatinib is not recommended during pregnancy or while breastfeeding due to potential risks to the fetus or infant. Women of childbearing age should use contraception during treatment.
• Liver and kidney function: Patients should be monitored for any liver or kidney problems, as Imatinib may affect both organs.
• Heart conditions: Patients with a history of heart disease, particularly congestive heart failure, should use Imatinib with caution.
• Infection risk: As Imatinib can affect white blood cell counts, it may increase the risk of infections. Regular monitoring of blood counts is essential during treatment.

Veenat 100mg Capsules (Imatinib) is a highly effective medication for treating cancers like CML and GISTs, by targeting specific molecular pathways that contribute to cancer growth. It has revolutionized cancer treatment, particularly in chronic leukemia and gastrointestinal cancers, but it requires careful monitoring for side effects, especially regarding blood counts, liver function, and fluid retention. Regular follow-up with a healthcare provider is crucial.